Dr. Masanori Nakayama

MPI-HLR, Indep. Research Group, Cell Polarity and Organogenesis

 

Cardiovascular disease and kidney dysfunction

 

Our laboratory is interested in examining mechanisms of cardiovascular disease and kidney dysfunction from a cell biology and biochemical perspective in order to identify novel disease mechanisms and therapeutic targets. The focus of our research is on two groups of proteins: Par polarity complex members and the ephrin/Eph system. Previously, we have shown that Par polarity complex members and ephrin B2 play important roles in regulating angiogenesis. We use conditional mouse genetic knockout models, in particular endothelial cell specific knockouts, to develop hypotheses from in vivo observations that can be linked to the pathophysiology of different diseases. The detailed mechanisms behind our in vivo observations are then rigorously examined using in vitro methodology, and extended into mouse disease models, and human samples when possible.

 

References:

(1) M. Nakayama et al. Spatial regulation of VEGF receptor endocytosis in angiogenesis; Nature Cell Biology, 2013. (2) Wang. Y, Nakayama M. et al. Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis; Nature, 2010.

 

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